海南医学院教案提要-海南医学院精品课程

　 海南医学院教案提要

　 2007～2008学年 第一学期 NO.1

　学科 medical microbiology 班级 undergraduate(04) 授 课 人 Huamin Wang 职 称 associate prof.

　课题 anti-infectious immunity(bilingual) 学时120 minutes 授课时间 2007.10.11 教学方式 CAI

　教学目的要求

　Objectives

　Aims and Objectives

　To understand how the body prevents entry of micro-organisms.

　To understand the difference between innate and acquired immunity.

　The student will acquire knowledge of the theoretical basics of immunology, which allow him/her to:

　 * comprehend：Acquired Immunity;Antibacterial responses;Anti- virus response.

　* understand：Innate Immunity;

　* recognize：Immune responses to fungi.

　2.内容提要、教学过程及学时分配

　Introduction 5 minutes

　 Mechanisms of Immunity

　Innate (Non-specific) Immunity 30 minutes

　Nature barriers

　Natural immune cells

　Humoral soluable molecule

　Acquired Immunity 30 minutes

　 Humoral Immune response

　Cellular Immune response

　Mucosal immune system,MIS 2 minutes

　Antibacterial responses 25 minutes

　Immune responses for extracellular bacterial Infections

　Immune responses for intracellular bacterial Infections

　Anti- virus response 20 minutes

　Non antigen-specific Immune response

　Antigen-specific Immune response

　Immune response to viral challenge

　Immune responses to fungi 3 minutes

　Summary

　 5 minutes

　3.重点、难点及解决方法

　key points: Acquired Immunity;Antibacterial responses;Anti- virus response.

　difficulty: Immune responses for intracellular bacterial Infections; Antigen-specific Immune response to virus.

　Methords to resolve:

　1.To review the knowledge which learned in Immonology

　2. Using images and animations help studengs know the mechanisms of immnunity.

　3. bilingua

　注：每次授课需用新教案；教研室于开课前检查，课完后统一上交。

　4.使用教具(写出主要内容的名称备查)

　PPT file:Anti-infectious Immunity

　5.本课题方面的新进展

　 There are many progesses in immunology. Such as following:

　1.Multiple Roles of Antimicrobial Defensins, Cathelicidins, and Eosinophil-Derived Neurotoxin in Host Defense.

　2.Starting at the Beginning: New Perspectives on the Biology of Mucosal T Cells.

　3.Immunological Memory to Viral Infections.

　4.Chemokines in Innate and Adaptive Host Defense: Basic Chemokinese Grammar for Immune Cells.

　6.板书的专用外语词汇（本科授课每学时至少3个）

　Anti-infectious Immunity Innate (Non-specific) Immunity Nature barriers Nature immune cells Humoral soluble molecule Phagocyte NK cell Mast cell Phagocytosis Opsonization Inflammatory response Complement Humoral Immune response Cellular Immune response

　Mucosal immune system(MIS) ADCC

　7.参考书籍

　正任主编《医学微生物学》（第六版，人民卫生出版社）

　闻玉梅主编《现代微生物学》

　Microbiology (fifth edition) (Lansing M.Prescott,etc. International Edition,ISBN0-07-112259-1)

　Medical microbiology (third edition) (Murry,etc. Mosby,ISBN0-8151-9035-2)

　Kuby Immunology (fouth edition) (Goldby,Richard, ISBN 0-7167-3331-5)

　8.思考题或/及作业

　（1）机体如何防御微生物感染？

　（2）机体如何记住原先感染的微生物，并在其再次感染时发挥更快和更有效的免疫应答？

　（3）机体的天然屏障有那些？

　（4）抗胞外菌免疫和抗胞内菌免疫有什么区别？

　（5）抗病毒免疫的特点是什么？

　（6）再次免疫应答主要由什么细胞发挥作用，有何特点？

　9.课后记及改进意见

　10.备注

　海南医学院教案提要

　2007～2008 学年 第一学期 NO.2

　学科 医学微生物学 班级 06本护、中 、中西 授 课 人 王华民 职 称 教授

　课题 肝炎病毒（HBV） 学时 3学时 授课时间 2007.12.19~20 教学方式 CAI（双语）

　1.教学目的要求

　 掌握：乙型肝炎病毒的病毒学特征、致病性与免疫性。

　 熟悉：肝炎病毒的概念，人类肝炎病毒的型别及其主要特征；乙型肝炎病毒病毒学检查法及人

　 工自动免疫的应用。

　 General Goal: To know the major causes of this disease, how they are transmitted, and the major manifestations of the disease.

　Specific Educational Objectives: The student should be able to:

　1.describe the common causes of blood-borne hepatitis and how they are transmitted. know the common means of transmission and what people groups are more likely to be infected.

　2. describe the major manifestations of this disease. Know what human cells the viruses replicate in.

　3. diagnose (infected or not) and stage (acute, window period, chronic, infectious, etc.) hepatitis B via serological testing. Therefore you should know the difference between a serological test for an antigen (HBsAg) and for an antibody (antiHBs).

　4．define the difference between acute infections, chronic infections, fulminant hepatitis, which hepatitis virus infections are more likely to result in hepatocellular carcinoma.

　5．describe how you can prevent hepatitis B infections.

　2.内容提要、教学过程及学时分配

　 1、组织教学并导入新课 5min

　 2、肝炎病毒的概念(General Concepts、Definitions for Hepatitises) 10min

　3、人类肝炎的型别及主要特征

　(Introduce to 6 types of hepatitis viruses & Viral Hepatitis) 10min

　 4、乙肝病毒Hepatitis B virus

　 生物学特性(Properties of HBV) 25 min

　 致病性与免疫性(Transmission、Pathogenesis & Immunology) 40 min

　 微生物学检查法(Laboratory_Diagnosis ) 15 min

　 防治原则（Treament & Prevention） 10 min

　 总结（summary） 5 min

　3.重点、难点及解决方法

　 重点：乙型肝炎病毒的病毒学特征、致病性与免疫性。

　 结合图表反复讲

　 难点：乙型肝炎病毒的基因结构、致病性与免疫性、乙肝两对半的分析。

　 结合图表通俗讲

　注：每次授课需用新教案；教研室于开课前检查，课完后统一上交。

　4.使用教具(写出主要内容的名称备查)

　CAI课件（自制）：肝炎病毒（HBV）（英语）

　5.本课题方面的新进展

　 变异株的研究、HBV受体研究、乙肝防治：

　乙肝病毒DNA聚合酶活性区发生变异与拉米夫定。

　人体基因多态性与HBV/HCV感染间关系：宿主在乙型肝炎病毒（hepatitis B virus，HBV）和丙型肝炎病毒（hepatitis C virus，HCV）感染后不同的临床发展过程，除了与病毒本身的因素有关外，更重要的是由于不同个体对HBV/HCV感染所发生的免疫反应的不同。人白细胞抗原（human leukocyte antigen，HLA）、细胞因子及细胞间粘附分子-1与机体免疫功能状态密切相关，并在乙、丙型肝炎免疫发病机理中起重要作用，其中某些基因的多态性可能导致机体免疫功能状态的差异，因而决定着HBV/HCV感染的不同临床转归。

　6.板书的专用外语词汇（本科授课每学时至少3个）

　 Hapatitis virus HBsAg HBeAg HBcAg PreS1 PreS2

　7.参考书籍

　周正任主编《医学微生物学》（第六版，人民卫生出版社）

　罗海波主编《现代医学细菌学》

　闻玉梅主编《现代微生物学》

　Microbiology (fifth edition) (Lansing M.Prescott,etc. International Edition,ISBN0-07-112259-1)

　Medical microbiology (third edition) (Murry,etc. Mosby,ISBN0-8151-9035-2)

　8.思考题或/及作业

　What is hepatitis B?

　What are the properties of HBV?

　How many ORFs of HBV?

　How is HBV spread?

　How does the HBV curse the liver diseases?

　How do you interpret serological lab results for HBV?

　How to treat and prevent hepatitis B?

　9.课后记及改进意见

　护理班班级小，效果好；中医及中西结合班级大，不如护理班。

　学生没有预习（补充教材发放慢），影响效果。

　互动不足

　10.备注